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Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation
Components of the prokaryotic clustered regularly interspersed palindromic repeat (CRISPR) loci have recently been repurposed for use in mammalian cells(1–6). The Cas9 protein can be programmed with a single guide RNA (sgRNA) to generate site-specific DNA breaks, but there are few known rules govern...
Gorde:
| Argitaratua izan da: | Nat Biotechnol |
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| Egile Nagusiak: | , , , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2014
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4262738/ https://ncbi.nlm.nih.gov/pubmed/25184501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3026 |
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