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Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
The CRISPR-Cas9 system provides the ability to edit, repress, activate, or mark any gene (or DNA element) by pairing of a programmable single guide RNA (sgRNA) with a complementary sequence on the DNA target. Here we present a new method for small-molecule control of CRISPR-Cas9 function through ins...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6509140/ https://ncbi.nlm.nih.gov/pubmed/31073154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09985-2 |
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