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Elimination of Specific miRNAs by Naked 14-nt sgRNAs

tRNase Z(L)-utilizing efficacious gene silencing (TRUE gene silencing) is a newly developed technology to suppress mammalian gene expression. TRUE gene silencing works on the basis of a unique enzymatic property of mammalian tRNase Z(L), which is that it can recognize a pre-tRNA-like or micro-pre-tR...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Takahashi, Masayuki, Elbarbary, Reyad A., Abe, Mayumi, Sato, Mari, Yoshida, Tetsuo, Yamada, Yoji, Tamura, Masato, Nashimoto, Masayuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3366928/
https://ncbi.nlm.nih.gov/pubmed/22675569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038496
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