Mimicking GEFs: A Common Theme For Bacterial Pathogens

Por Orchard, Robert C., Alto, Neal M.
Publicado em 2011

Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection

Por Orchard, Robert C., Wilen, Craig B., Virgin, Herbert W.
Publicado no Nat Microbiol (2018)

A systematic exploration of the interactions between bacterial effector proteins and host cell membranes

Por Weigele, Bethany A., Orchard, Robert C., Jimenez, Alyssa, Cox, Gregory W., Alto, Neal M.
Publicado no Nat Commun (2017)

Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit

Por Orchard, Robert C., Kittisopikul, Mark, Altschuler, Steven J., Wu, Lani F., Suel, Gurol M., Alto, Neal M.
Publicado em 2012

Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening

Por Orchard, Robert C., Sullender, Meagan E., Dunlap, Bria F., Balce, Dale R., Doench, John G., Virgin, Herbert W.
Publicado no J Virol (2018)

Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics

Por Huang, Zhiwei, Sutton, Sarah E, Wallenfang, Adam J, Orchard, Robert C, Wu, Xiaojing, Feng, Yingcai, Chai, Jijie, Alto, Neal M
Publicado no Nat Struct Mol Biol (2009)

The assembly of a GTPase–kinase signalling complex by a bacterial catalytic scaffold

Por Selyunin, Andrey S., Sutton, Sarah E., Weigele, Bethany A., Reddick, L. Evan, Orchard, Robert C., Bresson, Stefan M., Tomchick, Diana R., Alto, Neal M.
Publicado em 2010

A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells

Por Selleck, Elizabeth M., Orchard, Robert C., Lassen, Kara G., Beatty, Wandy L., Xavier, Ramnik J., Levine, Beth, Virgin, Herbert W., Sibley, L. David
Publicado no mBio (2015)

Norovirus Cell Tropism is Determined by Combinatorial Action of a Viral Non-structural Protein and Host Cytokine

Por Lee, Sanghyun, Wilen, Craig B., Orvedahl, Anthony, McCune, Broc T., Kim, Ki-Wook, Orchard, Robert C., Peterson, Stefan T., Nice, Timothy J., Baldridge, Megan T., Virgin, Herbert W.
Publicado no Cell Host Microbe (2017)

Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor

Por Nelson, Christopher A., Wilen, Craig B., Dai, Ya-Nan, Orchard, Robert C., Kim, Arthur S., Stegeman, Roderick A., Hsieh, Leon L., Smith, Thomas J., Virgin, Herbert W., Fremont, Daved H.
Publicado no Proc Natl Acad Sci U S A (2018)

Noncanonical autophagy inhibits the auto-inflammatory, lupus-like response to dying cells

Por Martinez, Jennifer, Cunha, Larissa D., Park, Sunmin, Yang, Mao, Lu, Qun, Orchard, Robert, Li, Quan-Zhen, Yan, Mei, Janke, Laura, Guy, Cliff, Linkermann, Andreas, Virgin, Herbert W., Green, Douglas R.
Publicado no Nature (2016)

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

Por Doench, John G., Fusi, Nicolo, Sullender, Meagan, Hegde, Mudra, Vaimberg, Emma W., Donovan, Katherine F., Smith, Ian, Tothova, Zuzana, Wilen, Craig, Orchard, Robert, Virgin, Herbert W., Listgarten, Jennifer, Root, David E.
Publicado no Nat Biotechnol (2016)

Molecular characterization of LC3-associated phagocytosis (LAP) reveals distinct roles for Rubicon, NOX2, and autophagy proteins

Por Martinez, Jennifer, Malireddi, RK Subbarao, Lu, Qun, Cunha, Larissa Dias, Pelletier, Stephane, Gingras, Sebastien, Orchard, Robert, Guan, Jun-Lin, Tan, Haiyan, Peng, Junmin, Kanneganti, Thirumala-Devi, Virgin, Herbert W., Green, Douglas R.
Publicado no Nat Cell Biol (2015)

Discovery of a proteinaceous cellular receptor for a norovirus

Por Orchard, Robert C., Wilen, Craig B., Doench, John G., Baldridge, Megan T., McCune, Broc T., Lee, Ying-Chiang J., Lee, Sanghyun, Pruett-Miller, Shondra M., Nelson, Christopher A., Fremont, Daved H., Virgin, Herbert W.
Publicado no Science (2016)

Viral replication complexes are targeted by LC3-guided interferon-inducible GTPases

Por Biering, Scott B., Choi, Jayoung, Halstrom, Rachel A., Brown, Hailey M., Beatty, Wandy L., Lee, Sanghyun, McCune, Broc T., Dominici, Erin, Williams, Lelia E., Orchard, Robert C., Wilen, Craig B., Yamamoto, Masahiro, Coers, Jörn, Taylor, Gregory A., Hwang, Seungmin
Publicado no Cell Host Microbe (2017)

Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival

Por Redmann, Veronika, Lamb, Christopher A., Hwang, Seungmin, Orchard, Robert C., Kim, Sungsu, Razi, Minoo, Milam, Ashley, Park, Sunmin, Yokoyama, Christine C., Kambal, Amal, Kreamalmeyer, Darren, Bosch, Marie K., Xiao, Maolei, Green, Karen, Kim, Jungsu, Pruett-Miller, Shondra M., Ornitz, David M., Allen, Paul M., Beatty, Wandy L., Schmidt, Robert E., DiAntonio, Aaron, Tooze, Sharon A., Virgin, Herbert W.
Publicado no Sci Rep (2016)

Tropism for tuft cells determines immune promotion of norovirus pathogenesis

Por Wilen, Craig B., Lee, Sanghyun, Hsieh, Lee-Yang, Orchard, Robert C., Desai, Chandni, Hykes, Barry L., McAllaster, Michael R., Balce, Dale R., Feehley, Taylor, Brestoff, Jonathan R., Hickey, Christina A., Yokoyama, Christine C., Wang, Ya-Ting, MacDuff, Donna A., Kreamalmayer, Darren, Howitt, Michael R., Neil, Jessica A., Cadwell, Ken, Allen, Paul M., Handley, Scott A., van Lookeren Campagne, Menno, Baldridge, Megan T., Virgin, Herbert W.
Publicado no Science (2018)