Noncanonical autophagy inhibits the auto-inflammatory, lupus-like response to dying cells

Defects in dying cell clearance are postulated to underlie the pathogenesis of systemic lupus erythematosus (SLE)(1). Mice lacking molecules associated with dying cell clearance develop SLE-like disease(2), and phagocytes from SLE patients often display defective clearance and increased inflammatory...

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Publicado no:Nature
Main Authors: Martinez, Jennifer, Cunha, Larissa D., Park, Sunmin, Yang, Mao, Lu, Qun, Orchard, Robert, Li, Quan-Zhen, Yan, Mei, Janke, Laura, Guy, Cliff, Linkermann, Andreas, Virgin, Herbert W., Green, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860026/
https://ncbi.nlm.nih.gov/pubmed/27096368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature17950
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