Noncanonical function of an autophagy protein prevents spontaneous Alzheimer’s disease

Noncanonical functions of autophagy proteins have been implicated in neurodegenerative conditions, including Alzheimer’s disease (AD). The WD domain of the autophagy protein Atg16L is dispensable for canonical autophagy but required for its noncanonical functions. Two-year-old mice lacking this doma...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Heckmann, Bradlee L., Teubner, Brett J. W., Boada-Romero, Emilio, Tummers, Bart, Guy, Clifford, Fitzgerald, Patrick, Mayer, Ulrike, Carding, Simon, Zakharenko, Stanislav S., Wileman, Thomas, Green, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428329/
https://ncbi.nlm.nih.gov/pubmed/32851186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb9036
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