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LC3-associated endocytosis facilitates β-amyloid clearance and mitigates neurodegeneration in murine Alzheimer’s Disease
The expression of some proteins in the autophagy pathway decline with age, which may impact neurodegeneration in diseases, including Alzheimer’s Disease. We have identified a novel non-canonical function of several autophagy proteins in the conjugation of LC3 to Rab5(+), clathrin(+) endosomes contai...
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| Pubblicato in: | Cell |
|---|---|
| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6689199/ https://ncbi.nlm.nih.gov/pubmed/31257024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.05.056 |
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