Molecular characterization of LC3-associated phagocytosis (LAP) reveals distinct roles for Rubicon, NOX2, and autophagy proteins

LC3-associated phagocytosis (LAP) is a process wherein elements of canonical autophagy conjugate LC3 to the membranes of phagosomes, facilitating maturation upon fusion to lysosomes. Here, we characterize the molecular requirements for LAP, and identify a protein, Rubicon, required for LAP but not c...

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Vydáno v:Nat Cell Biol
Hlavní autoři: Martinez, Jennifer, Malireddi, RK Subbarao, Lu, Qun, Cunha, Larissa Dias, Pelletier, Stephane, Gingras, Sebastien, Orchard, Robert, Guan, Jun-Lin, Tan, Haiyan, Peng, Junmin, Kanneganti, Thirumala-Devi, Virgin, Herbert W., Green, Douglas R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4612372/
https://ncbi.nlm.nih.gov/pubmed/26098576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3192
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