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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses

Constitutive expression of telomerase prevents senescence and crisis by maintaining telomere homeostasis. However, recent evidence suggests that telomerase is dynamically regulated in normal cells and also contributes to transformation independently of net telomere elongation. Here, we show that sup...

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Detalhes bibliográficos
Main Authors: Masutomi, Kenkichi, Possemato, Richard, Wong, Judy M. Y., Currier, Jennifer L., Tothova, Zuzana, Manola, Judith B., Ganesan, Shridar, Lansdorp, Peter M., Collins, Kathleen, Hahn, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1149439/
https://ncbi.nlm.nih.gov/pubmed/15928077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503095102
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