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Telomerase reverse transcriptase moonlights: Therapeutic targets beyond telomerase

Telomeres, the repetitive sequences at chromosomal ends, protect intact chromosomes. Telomeres progressively shorten through successive rounds of cell divisions, and critically shortened telomeres trigger senescence and apoptosis. The enzyme that elongates telomeres and maintains their structure is...

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Publicat a:Cancer Sci
Autors principals: Maida, Yoshiko, Masutomi, Kenkichi
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714691/
https://ncbi.nlm.nih.gov/pubmed/26331588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12806
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