AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias

AKT activation is associated with many malignancies, where AKT acts, in part, by inhibiting FOXO tumor suppressors. We show a converse role for AKT/FOXOs in acute myeloid leukemia (AML). Rather than decreased FOXO activity, we observed that FOXOs are active in ∼40% of AML patient samples regardless...

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Detalhes bibliográficos
Main Authors: Sykes, Stephen M., Lane, Steven W., Bullinger, Lars, Kalaitzidis, Demetrios, Yusuf, Rushdia, Saez, Borja, Ferraro, Francesca, Mercier, Francois, Singh, Harshabad, Brumme, Kristina M., Acharya, Sanket S., Scholl, Claudia, Tothova, Zuzana, Attar, Eyal C., Fröhling, Stefan, DePinho, Ronald A., Gilliland, D. Gary, Armstrong, Scott A., Scadden, David T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826540/
https://ncbi.nlm.nih.gov/pubmed/21884932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.07.032
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