FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis

mTORC1 is a validated therapeutic target for renal cell carcinoma (RCC). Here, analysis of Tsc1 deficient (mTORC1 hyperactivation) mice uncovered a FoxO-dependent negative feedback circuit constraining mTORC1-mediated renal tumorigenesis. We document robust FoxO activation in Tsc1 deficient benign p...

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書誌詳細
主要な著者: Gan, Boyi, Lim, Carol, Chu, Gerald, Hua, Sujun, Ding, Zhihu, Collins, Michael, Hu, Jian, Jiang, Shan, Fletcher-Sananikone, Eliot, Zhuang, Li, Chang, Michelle, Zheng, Hongwu, Wang, Y. Alan, Kwiatkowski, David J., Kaelin, William G, Signoretti, Sabina, DePinho, Ronald A
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3023886/
https://ncbi.nlm.nih.gov/pubmed/21075312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2010.10.019
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