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Are therapeutic effects of antiacne agents mediated by activation of FoxO1 and inhibition of mTORC1?
Acne pathogenesis has recently been linked to decreased nuclear FoxO1 levels and increased mTORC1 activity. This hypothesis postulates that antiacne agents either enhance nuclear FoxO activity or inhibit mTORC1. Benzoyl peroxide (BPO), by activation of oxidative stress-inducible kinases, increases n...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3746104/ https://ncbi.nlm.nih.gov/pubmed/23800068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/exd.12172 |
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