FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor

FoxO transcription factors and TORC1 are conserved downstream effectors of Akt. Here we unraveled regulatory circuits underlying interplay between Akt, FoxO, and mTOR. Activated FoxO1 inhibits mTORC1 by TSC2-dependent and TSC2-independent mechanisms. First, FoxO1 binds the promoter region of Sestrin...

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Detalhes bibliográficos
Main Authors: Chen, Chia-Chen, Jeon, Sang-Min, Bhaskar, Prashanth T., Nogueira, Veronique, Sundararajan, Deepa, Tonic, Ivana, Park, Youngkyu, Hay, Nissim
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031984/
https://ncbi.nlm.nih.gov/pubmed/20412774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.03.008
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