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FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor
FoxO transcription factors and TORC1 are conserved downstream effectors of Akt. Here we unraveled regulatory circuits underlying interplay between Akt, FoxO, and mTOR. Activated FoxO1 inhibits mTORC1 by TSC2-dependent and TSC2-independent mechanisms. First, FoxO1 binds the promoter region of Sestrin...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3031984/ https://ncbi.nlm.nih.gov/pubmed/20412774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2010.03.008 |
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