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p53 Strikes mTORC1 by Employing Sestrins
The guardian of the genome (p53) elicits cell-cycle checkpoints in response to genotoxic stress. p53 also induces a metabolic checkpoint by inhibiting the mammalian target of rapamycin complex 1 (mTORC1). Recent results by Budanov and Karin, (2008) reveal that p53 exerts its effect on mTORC1 through...
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| Publié dans: | Cell Metab |
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| Auteur principal: | |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5744681/ https://ncbi.nlm.nih.gov/pubmed/18762019 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.08.010 |
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