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SESTRINs regulate mTORC1 via RRAGs: The riddle of GATOR
SESTRINs, proteins encoded by the SESN1–3 genes in mammals, are well-established suppressors of the mechanistic target of rapamycin complex 1 (mTORC1) kinase. Recently, we found that SESTRINs bind the GATOR2 protein complex, which is a regulator of RRAGA/B guanosine triphosphatase. Three independent...
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| Published in: | Mol Cell Oncol |
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| Main Author: | |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Taylor & Francis
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4905323/ https://ncbi.nlm.nih.gov/pubmed/27308486 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2014.997113 |
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