Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

Sestrins are stress-inducible metabolic regulators that suppress a wide range of age- and obesity-associated pathologies, many of which are due to mTORC1 overactivation. Upon various stresses, the Sestrins inhibit mTORC1 activity through an indirect mechanism that is still unclear. GATORs are recent...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Kim, Jeong Sig, Ro, Seung-Hyun, Kim, Myungjin, Park, Hwan-Woo, Semple, Ian A., Park, Haeli, Cho, Uhn-Soo, Wang, Wei, Guan, Kun-Liang, Karin, Michael, Lee, Jun Hee
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377584/
https://ncbi.nlm.nih.gov/pubmed/25819761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09502
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