Sestrins Inhibit mTORC1 Kinase Activation Through the GATOR Complex

The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a sensor of different environmental conditions and regulator of cell growth, metabolism and autophagy. mTORC1 is activated by Rag GTPases, working as RagA:B and RagC:D heterodimers. Rags control mTORC1 activity by tethering mTORC1 to t...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Parmigiani, Anita, Nourbakhsh, Aida, Ding, Boxiao, Wang, Wei, Kim, Young Chul, Akopiants, Konstantin, Guan, Kun-Liang, Karin, Michael, Budanov, Andrei V.
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303546/
https://ncbi.nlm.nih.gov/pubmed/25457612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.019
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