The GATOR2–mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation

Sestrins represent a family of stress-inducible proteins that prevent the progression of many age- and obesity-associated disorders. Endogenous Sestrins maintain insulin-dependent AKT Ser/Thr kinase (AKT) activation during high-fat diet–induced obesity, and overexpressed Sestrins activate AKT in var...

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Published in:J Biol Chem
Main Authors: Kowalsky, Allison Ho, Namkoong, Sim, Mettetal, Eric, Park, Hwan-Woo, Kazyken, Dubek, Fingar, Diane C., Lee, Jun Hee
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7029113/
https://ncbi.nlm.nih.gov/pubmed/31915252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010857
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