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The GATOR2–mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation
Sestrins represent a family of stress-inducible proteins that prevent the progression of many age- and obesity-associated disorders. Endogenous Sestrins maintain insulin-dependent AKT Ser/Thr kinase (AKT) activation during high-fat diet–induced obesity, and overexpressed Sestrins activate AKT in var...
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| Publicat a: | J Biol Chem |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7029113/ https://ncbi.nlm.nih.gov/pubmed/31915252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010857 |
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