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The Sestrins interact with GATOR2 to negatively regulate the amino acid sensing pathway upstream of mTORC1
The mTORC1 kinase is a major regulator of cell growth that responds to numerous environmental cues. A key input is amino acids, which act through the heterodimeric Rag GTPases (RagA/B bound to RagC/D) to promote the translocation of mTORC1 to the lysosomal surface, its site of activation. GATOR2 is...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4223866/ https://ncbi.nlm.nih.gov/pubmed/25263562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.09.014 |
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