Sestrin2 is a leucine sensor for the mTORC1 pathway

af Wolfson, Rachel L., Chantranupong, Lynne, Saxton, Robert A., Shen, Kuang, Scaria, Sonia M., Cantor, Jason R., Sabatini, David M.
Udgivet i Science (2015)

Dihydroxyacetone phosphate signals glucose availability to mTORC1

af Orozco, Jose M., Krawczyk, Patrycja A., Scaria, Sonia M., Cangelosi, Andrew L., Chan, Sze Ham, Kunchok, Tenzin, Lewis, Caroline A., Sabatini, David M.
Udgivet i Nat Metab (2020)

The Sestrins interact with GATOR2 to negatively regulate the amino acid sensing pathway upstream of mTORC1

af Chantranupong, Lynne, Wolfson, Rachel L., Orozco, Jose M., Saxton, Robert A., Scaria, Sonia M., Bar-Peled, Liron, Spooner, Eric, Isasa, Marta, Gygi, Steven P., Sabatini, David M.
Udgivet i Cell Rep (2014)

The CASTOR proteins are arginine sensors for the mTORC1 pathway

af Chantranupong, Lynne, Scaria, Sonia M., Saxton, Robert A., Gygi, Melanie P., Shen, Kuang, Wyant, Gregory A., Wang, Tim, Harper, J. Wade, Gygi, Steven P., Sabatini, David M.
Udgivet i Cell (2016)

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway

af Gu, Xin, Orozco, Jose M., Saxton, Robert A., Condon, Kendall J., Liu, Grace Y., Krawczyk, Patrycja A., Scaria, Sonia M., Harper, J. Wade, Gygi, Steven P., Sabatini, David M.
Udgivet i Science (2017)

Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs

af Jost, Marco, Santos, Daniel A., Saunders, Reuben A., Horlbeck, Max A., Hawkins, John S., Scaria, Sonia M., Norman, Thomas M., Hussmann, Jeffrey A., Liem, Christina R., Gross, Carol A., Weissman, Jonathan S.
Udgivet i Nat Biotechnol (2020)

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

af Wolfson, Rachel L., Chantranupong, Lynne, Wyant, Gregory A., Gu, Xin, Orozco, Jose M., Shen, Kuang, Condon, Kendall J., Petri, Sabrina, Kedir, Jibril, Scaria, Sonia M., Abu-Remaileh, Monther, Frankel, Wayne N., Sabatini, David M.
Udgivet i Nature (2017)