mTOR Signaling in Growth, Metabolism, and Disease

door Saxton, Robert A., Sabatini, David M.
Gepubliceerd in Cell (2017)

The apo-structure of the leucine sensor Sestrin2 is still elusive

door Saxton, Robert A., Knockenhauer, Kevin E., Schwartz, Thomas U., Sabatini, David M.
Gepubliceerd in Sci Signal (2016)

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

door Saxton, Robert A., Chantranupong, Lynne, Knockenhauer, Kevin E., Schwartz, Thomas U., Sabatini, David M.
Gepubliceerd in Nature (2016)

The Tissue Protective Functions of Interleukin-22 can be Decoupled from Pro-Inflammatory Actions Through Structure-Based Design

door Saxton, Robert A., Henneberg, Lukas T., Calafiore, Marco, Su, Leon, Jude, Kevin M., Hanash, Alan M., Garcia, K. Christopher
Gepubliceerd in Immunity (2021)

Sestrin2 is a leucine sensor for the mTORC1 pathway

door Wolfson, Rachel L., Chantranupong, Lynne, Saxton, Robert A., Shen, Kuang, Scaria, Sonia M., Cantor, Jason R., Sabatini, David M.
Gepubliceerd in Science (2015)

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

door Saxton, Robert A., Knockenhauer, Kevin E., Wolfson, Rachel L., Chantranupong, Lynne, Pacold, Michael E., Wang, Tim, Schwartz, Thomas U., Sabatini, David M.
Gepubliceerd in Science (2015)

The Sestrins interact with GATOR2 to negatively regulate the amino acid sensing pathway upstream of mTORC1

door Chantranupong, Lynne, Wolfson, Rachel L., Orozco, Jose M., Saxton, Robert A., Scaria, Sonia M., Bar-Peled, Liron, Spooner, Eric, Isasa, Marta, Gygi, Steven P., Sabatini, David M.
Gepubliceerd in Cell Rep (2014)

The CASTOR proteins are arginine sensors for the mTORC1 pathway

door Chantranupong, Lynne, Scaria, Sonia M., Saxton, Robert A., Gygi, Melanie P., Shen, Kuang, Wyant, Gregory A., Wang, Tim, Harper, J. Wade, Gygi, Steven P., Sabatini, David M.
Gepubliceerd in Cell (2016)

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway

door Gu, Xin, Orozco, Jose M., Saxton, Robert A., Condon, Kendall J., Liu, Grace Y., Krawczyk, Patrycja A., Scaria, Sonia M., Harper, J. Wade, Gygi, Steven P., Sabatini, David M.
Gepubliceerd in Science (2017)

Topological control of cytokine receptor signaling induces differential effects in hematopoiesis

door Mohan, Kritika, Ueda, George, Kim, Ah Ram, Jude, Kevin M., Fallas, Jorge A., Guo, Yu, Hafer, Maximillian, Miao, Yi, Saxton, Robert A., Piehler, Jacob, Sankaran, Vijay G., Baker, David, Garcia, K. Christopher
Gepubliceerd in Science (2019)