The CASTOR proteins are arginine sensors for the mTORC1 pathway

Amino acids signal to the mTOR complex I (mTORC1) growth pathway through the Rag GTPases. Multiple distinct complexes regulate the Rags, including GATOR1, a GTPase activating protein (GAP), and GATOR2, a positive regulator of unknown molecular function. Arginine stimulation of cells activates mTORC1...

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Publicat a:Cell
Autors principals: Chantranupong, Lynne, Scaria, Sonia M., Saxton, Robert A., Gygi, Melanie P., Shen, Kuang, Wyant, Gregory A., Wang, Tim, Harper, J. Wade, Gygi, Steven P., Sabatini, David M.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4808398/
https://ncbi.nlm.nih.gov/pubmed/26972053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.02.035
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