“Take it up a NOTCH: ” Novel strategies for cancer therapy

af Morgan, Stefanie L., Wyant, Gregory A., Dinulescu, Daniela M.
Udgivet 2013

A PEROXO-Tag Enables Rapid Isolation of Peroxisomes from Human Cells

af Ray, G. Jordan, Boydston, Elizabeth A., Shortt, Emily, Wyant, Gregory A., Lourido, Sebastian, Chen, Walter W., Sabatini, David M.
Udgivet i iScience (2020)

Lysosomal metabolomics reveals V-ATPase and mTOR-dependent regulation of amino acid efflux from lysosomes

af Abu-Remaileh, Monther, Wyant, Gregory A., Kim, Choah, Laqtom, Nouf N., Abbasi, Maria, Chan, Sze Ham, Freinkman, Elizaveta, Sabatini, David M.
Udgivet i Science (2017)

mTORC1 activator SLC38A9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient

af Wyant, Gregory A., Abu-Remaileh, Monther, Wolfson, Rachel L., Chen, Walter W., Freinkman, Elizaveta, Danai, Laura V., Vander Heiden, Matthew G., Sabatini, David M.
Udgivet i Cell (2017)

The CASTOR proteins are arginine sensors for the mTORC1 pathway

af Chantranupong, Lynne, Scaria, Sonia M., Saxton, Robert A., Gygi, Melanie P., Shen, Kuang, Wyant, Gregory A., Wang, Tim, Harper, J. Wade, Gygi, Steven P., Sabatini, David M.
Udgivet i Cell (2016)

NUFIP1 is a ribosome receptor for starvation-induced ribophagy

af Wyant, Gregory A., Abu-Remaileh, Monther, Frenkel, Evgeni M., Laqtom, Nouf N., Dharamdasani, Vimisha, Lewis, Caroline A., Chan, Sze Ham, Heinze, Ivonne, Ori, Alessandro, Sabatini, David M.
Udgivet i Science (2018)

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

af Yu, Zhou, Surface, Lauren E, Park, Chong Yon, Horlbeck, Max A, Wyant, Gregory A, Abu-Remaileh, Monther, Peterson, Timothy R, Sabatini, David M, Weissman, Jonathan S, O'Shea, Erin K
Udgivet i eLife (2018)

Supramolecular nanoparticles that target phosphatidylinositol-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy

af Kulkarni, Ashish A., Roy, Bhaskar, Rao, Poornima S., Wyant, Gregory A., Mahmoud, Ayaat, Ramachandran, Madhumitha, Sengupta, Poulomi, Goldman, Aaron, Kotamraju, Venkata Ramana, Basu, Sudipta, Mashelkar, Raghunath A, Ruoslahti, Erkki, Dinulescu, Daniela M., Sengupta, Shiladitya
Udgivet 2013

SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

af Kory, Nora, Wyant, Gregory A., Prakash, Gyan, de Bos, Jelmi uit, Bottanelli, Francesca, Pacold, Michael E., Chan, Sze Ham, Lewis, Caroline A., Wang, Tim, Keys, Heather R., Guo, Yang Eric, Sabatini, David M.
Udgivet i Science (2018)

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

af Wolfson, Rachel L., Chantranupong, Lynne, Wyant, Gregory A., Gu, Xin, Orozco, Jose M., Shen, Kuang, Condon, Kendall J., Petri, Sabrina, Kedir, Jibril, Scaria, Sonia M., Abu-Remaileh, Monther, Frankel, Wayne N., Sabatini, David M.
Udgivet i Nature (2017)

Transformation of the Fallopian Tube Secretory Epithelium Leads to High-grade Serous Ovarian Cancer in Brca;Tp53;Pten Models

af Perets, Ruth, Wyant, Gregory A., Muto, Katherine W., Bijron, Jonathan G., Poole, Barish B., Chin, Kenneth T., Chen, Jin Yun H., Ohman, Anders W., Stepule, Corey D., Kwak, Soongu, Karst, Alison M., Hirsch, Michelle S., Setlur, Sunita R., Crum, Christopher P., Dinulescu, Daniela M., Drapkin, Ronny
Udgivet 2013

The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1

af Wang, Shuyu, Tsun, Zhi-Yang, Wolfson, Rachel, Shen, Kuang, Wyant, Gregory A., Plovanich, Molly E., Yuan, Elizabeth D., Jones, Tony D., Chantranupong, Lynne, Comb, William, Wang, Tim, Bar-Peled, Liron, Zoncu, Roberto, Straub, Christoph, Kim, Choah, Park, Jiwon, Sabatini, Bernardo L., Sabatini, David M.
Udgivet i Science (2015)

Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy

af McAuliffe, Shannon M., Morgan, Stefanie L., Wyant, Gregory A., Tran, Lieu T., Muto, Katherine W., Chen, Yu Sarah, Chin, Kenneth T., Partridge, Justin C., Poole, Barish B., Cheng, Kuang-Hung, Daggett, John, Cullen, Kristen, Kantoff, Emily, Hasselbatt, Kathleen, Berkowitz, Julia, Muto, Michael G., Berkowitz, Ross S., Aster, Jon C., Matulonis, Ursula A., Dinulescu, Daniela M.
Udgivet 2012