mTORC1 activator SLC38A9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient

The mTORC1 kinase is a master growth regulator that senses many environmental cues, including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9 is an arginine sensor...

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Gepubliceerd in:Cell
Hoofdauteurs: Wyant, Gregory A., Abu-Remaileh, Monther, Wolfson, Rachel L., Chen, Walter W., Freinkman, Elizaveta, Danai, Laura V., Vander Heiden, Matthew G., Sabatini, David M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704964/
https://ncbi.nlm.nih.gov/pubmed/29053970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.046
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