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mTORC1 activator SLC38A9 is required to efflux essential amino acids from lysosomes and use protein as a nutrient
The mTORC1 kinase is a master growth regulator that senses many environmental cues, including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9 is an arginine sensor...
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| Pubblicato in: | Cell |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5704964/ https://ncbi.nlm.nih.gov/pubmed/29053970 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.046 |
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