SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

One-carbon metabolism generates the one-carbon units required to synthesize many critical metabolites, including nucleotides. The pathway has cytosolic and mitochondrial branches, and a key step is the entry, through an unknown mechanism, of serine into mitochondria, where it is converted into glyci...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Science
Prif Awduron: Kory, Nora, Wyant, Gregory A., Prakash, Gyan, de Bos, Jelmi uit, Bottanelli, Francesca, Pacold, Michael E., Chan, Sze Ham, Lewis, Caroline A., Wang, Tim, Keys, Heather R., Guo, Yang Eric, Sabatini, David M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6300058/
https://ncbi.nlm.nih.gov/pubmed/30442778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aat9528
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