The Folliculin tumor suppressor is a GAP for RagC/D GTPases that signal amino acid levels to mTORC1

Por Tsun, Zhi-Yang, Bar-Peled, Liron, Chantranupong, Lynne, Zoncu, Roberto, Wang, Tim, Kim, Choah, Spooner, Eric, Sabatini, David M.
Publicado em 2013

Lysosomal metabolomics reveals V-ATPase and mTOR-dependent regulation of amino acid efflux from lysosomes

Por Abu-Remaileh, Monther, Wyant, Gregory A., Kim, Choah, Laqtom, Nouf N., Abbasi, Maria, Chan, Sze Ham, Freinkman, Elizaveta, Sabatini, David M.
Publicado no Science (2017)

The amino acid transporter SLC38A9 is a key component of a lysosomal membrane complex that signals arginine sufficiency to mTORC1

Por Wang, Shuyu, Tsun, Zhi-Yang, Wolfson, Rachel, Shen, Kuang, Wyant, Gregory A., Plovanich, Molly E., Yuan, Elizabeth D., Jones, Tony D., Chantranupong, Lynne, Comb, William, Wang, Tim, Bar-Peled, Liron, Zoncu, Roberto, Straub, Christoph, Kim, Choah, Park, Jiwon, Sabatini, Bernardo L., Sabatini, David M.
Publicado no Science (2015)