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The Folliculin tumor suppressor is a GAP for RagC/D GTPases that signal amino acid levels to mTORC1
The mTORC1 kinase is a master growth regulator that senses numerous environmental cues, including amino acids. The Rag GTPases interact with mTORC1 and signal amino acid sufficiency by promoting the translocation of mTORC1 to the lysosomal surface, its site of activation. The Rags are unusual GTPase...
Tallennettuna:
| Päätekijät: | , , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2013
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3867817/ https://ncbi.nlm.nih.gov/pubmed/24095279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.09.016 |
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