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An expanded Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1
The mTOR Complex 1 (mTORC1) pathway promotes cell growth in response to a diverse set of cues, including growth factors as well as energy and amino acid levels. Amino acids signal through the Rag GTPases to promote the translocation of mTORC1 to the lysosomal surface, its site of activation. The fou...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3517996/ https://ncbi.nlm.nih.gov/pubmed/22980980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.07.032 |
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