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An expanded Ragulator is a GEF for the Rag GTPases that signal amino acid levels to mTORC1

The mTOR Complex 1 (mTORC1) pathway promotes cell growth in response to a diverse set of cues, including growth factors as well as energy and amino acid levels. Amino acids signal through the Rag GTPases to promote the translocation of mTORC1 to the lysosomal surface, its site of activation. The fou...

詳細記述

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書誌詳細
主要な著者: Bar-Peled, Liron, Schweitzer, Lawrence D., Zoncu, Roberto, Sabatini, David M.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3517996/
https://ncbi.nlm.nih.gov/pubmed/22980980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.07.032
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