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Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1

mTORC1 controls key processes that regulate cell growth, including mRNA translation, ribosome biogenesis, and autophagy. Environmental amino acids activate mTORC1 by promoting its recruitment to the cytosolic surface of the lysosome, where its kinase is activated downstream of growth factor signalin...

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Detalhes bibliográficos
Main Authors: Lawrence D. Schweitzer, William C. Comb, Liron Bar-Peled, David M. Sabatini
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015-09-01
Colecção:Cell Reports
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S221112471500830X
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