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Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex

The lysosomal membrane is the locus for sensing cellular nutrient levels, which are transduced to mTORC1 via the Rag GTPases and the Ragulator complex. The crystal structure of the five-subunit human Ragulator at 1.4 Å resolution was determined. Lamtor1 wraps around the other four subunits to stabil...

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Détails bibliographiques
Publié dans:Mol Cell
Auteurs principaux: Su, Ming-Yuan, Morris, Kyle L., Kim, Do Jin, Fu, Yangxue, Lawrence, Rosalie, Stjepanovic, Goran, Zoncu, Roberto, Hurley, James H.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722659/
https://ncbi.nlm.nih.gov/pubmed/29107538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.10.016
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