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Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex
The lysosomal membrane is the locus for sensing cellular nutrient levels, which are transduced to mTORC1 via the Rag GTPases and the Ragulator complex. The crystal structure of the five-subunit human Ragulator at 1.4 Å resolution was determined. Lamtor1 wraps around the other four subunits to stabil...
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| Gepubliceerd in: | Mol Cell |
|---|---|
| Hoofdauteurs: | , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5722659/ https://ncbi.nlm.nih.gov/pubmed/29107538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.10.016 |
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