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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

The multiprotein mTORC1 protein kinase complex is the central component of a pathway that promotes growth in response to insulin, energy levels, and amino acids, and is deregulated in common cancers. We find that the Rag proteins—a family of four related small guanosine triphosphatases (GTPases)—int...

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Bibliographische Detailangaben
Hauptverfasser: Sancak, Yasemin, Peterson, Timothy R., Shaul, Yoav D., Lindquist, Robert A., Thoreen, Carson C., Bar-Peled, Liron, Sabatini, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2475333/
https://ncbi.nlm.nih.gov/pubmed/18497260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1157535
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