Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy

Chemoresistance to platinum therapy is a major obstacle that needs to be overcome in the treatment of ovarian cancer patients. The high rates and patterns of therapeutic failure seen in patients are consistent with a steady accumulation of drug-resistant cancer stem cells (CSCs). This study demonstr...

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Main Authors: McAuliffe, Shannon M., Morgan, Stefanie L., Wyant, Gregory A., Tran, Lieu T., Muto, Katherine W., Chen, Yu Sarah, Chin, Kenneth T., Partridge, Justin C., Poole, Barish B., Cheng, Kuang-Hung, Daggett, John, Cullen, Kristen, Kantoff, Emily, Hasselbatt, Kathleen, Berkowitz, Julia, Muto, Michael G., Berkowitz, Ross S., Aster, Jon C., Matulonis, Ursula A., Dinulescu, Daniela M.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2012
主題:
PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3491453/
https://ncbi.nlm.nih.gov/pubmed/23019585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206400109
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