Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development

Zfp57 is a maternal–zygotic effect gene that maintains genomic imprinting. Here we report that Zfp57 mutants exhibited a variety of cardiac defects including atrial septal defect (ASD), ventricular septal defect (VSD), thin myocardium, and reduced trabeculation. Zfp57 maternal-zygotic mutant embryos...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Shamis, Yulia, Cullen, Dana E., Liu, Lizhi, Yang, Guan, Ng, Sheau-Fang, Xiao, Lijuan, Bell, Fong T., Ray, Chelsea, Takikawa, Sachiko, Moskowitz, Ivan P., Cai, Chen-Leng, Yang, Xiao, Li, Xiajun
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413352/
https://ncbi.nlm.nih.gov/pubmed/25848000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415541112
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