Transformation of the Fallopian Tube Secretory Epithelium Leads to High-grade Serous Ovarian Cancer in Brca;Tp53;Pten Models

High-grade serous ovarian carcinoma presents significant clinical and therapeutic challenges. Although the traditional model of carcinogenesis has focused on the ovary as a tumor initiation site, recent studies suggest that there may be additional sites of origin outside the ovary, namely the secret...

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Detalhes bibliográficos
Main Authors: Perets, Ruth, Wyant, Gregory A., Muto, Katherine W., Bijron, Jonathan G., Poole, Barish B., Chin, Kenneth T., Chen, Jin Yun H., Ohman, Anders W., Stepule, Corey D., Kwak, Soongu, Karst, Alison M., Hirsch, Michelle S., Setlur, Sunita R., Crum, Christopher P., Dinulescu, Daniela M., Drapkin, Ronny
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3917315/
https://ncbi.nlm.nih.gov/pubmed/24332043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.10.013
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