Supramolecular nanoparticles that target phosphatidylinositol-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy

The centrality of phosphatidylinositol-3-kinase (PI3K) in cancer etiology is well established, but clinical translation of PI3K inhibitors has been limited by feedback signaling, suboptimal intra-tumoral concentration and an insulin resistance ‘class effect’. The current study was designed to explor...

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Main Authors: Kulkarni, Ashish A., Roy, Bhaskar, Rao, Poornima S., Wyant, Gregory A., Mahmoud, Ayaat, Ramachandran, Madhumitha, Sengupta, Poulomi, Goldman, Aaron, Kotamraju, Venkata Ramana, Basu, Sudipta, Mashelkar, Raghunath A, Ruoslahti, Erkki, Dinulescu, Daniela M., Sengupta, Shiladitya
פורמט: Artigo
שפה:Inglês
יצא לאור: 2013
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855341/
https://ncbi.nlm.nih.gov/pubmed/24121488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4477
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