Supramolecular nanoparticles that target phosphatidylinositol-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy

The centrality of phosphatidylinositol-3-kinase (PI3K) in cancer etiology is well established, but clinical translation of PI3K inhibitors has been limited by feedback signaling, suboptimal intra-tumoral concentration and an insulin resistance ‘class effect’. The current study was designed to explor...

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Detalhes bibliográficos
Main Authors: Kulkarni, Ashish A., Roy, Bhaskar, Rao, Poornima S., Wyant, Gregory A., Mahmoud, Ayaat, Ramachandran, Madhumitha, Sengupta, Poulomi, Goldman, Aaron, Kotamraju, Venkata Ramana, Basu, Sudipta, Mashelkar, Raghunath A, Ruoslahti, Erkki, Dinulescu, Daniela M., Sengupta, Shiladitya
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855341/
https://ncbi.nlm.nih.gov/pubmed/24121488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4477
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