Supramolecular nanoparticles that target phosphatidylinositol-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy

The centrality of phosphatidylinositol-3-kinase (PI3K) in cancer etiology is well established, but clinical translation of PI3K inhibitors has been limited by feedback signaling, suboptimal intra-tumoral concentration and an insulin resistance ‘class effect’. The current study was designed to explor...

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Main Authors: Kulkarni, Ashish A., Roy, Bhaskar, Rao, Poornima S., Wyant, Gregory A., Mahmoud, Ayaat, Ramachandran, Madhumitha, Sengupta, Poulomi, Goldman, Aaron, Kotamraju, Venkata Ramana, Basu, Sudipta, Mashelkar, Raghunath A, Ruoslahti, Erkki, Dinulescu, Daniela M., Sengupta, Shiladitya
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2013
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3855341/
https://ncbi.nlm.nih.gov/pubmed/24121488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-4477
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