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Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
Eukaryotic cells coordinate growth with the availability of nutrients through mTOR complex 1 (mTORC1), a master growth regulator. Leucine is of particular importance and activates mTORC1 via the Rag GTPases and their regulators GATOR1 and GATOR2. Sestrin2 interacts with GATOR2 and is a leucine senso...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4698039/ https://ncbi.nlm.nih.gov/pubmed/26586190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad2087 |
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