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Leucine Induced Dephosphorylation of Sestrin2 Promotes mTORC1 Activation

The studies described herein were designed to explore the role of Sestrin2 in mediating the selective action of leucine to activate mTORC1. The results demonstrate that Sestrin2 is a phosphoprotein and that its phosphorylation state is responsive to the availability of leucine, but not other essenti...

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Pubblicato in:Cell Signal
Autori principali: Kimball, Scot R., Gordon, Bradley S., Moyer, Jenna E., Dennis, Michael D., Jefferson, Leonard S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899281/
https://ncbi.nlm.nih.gov/pubmed/27010498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2016.03.008
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