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Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle

Previous studies established that leucine stimulates protein synthesis in skeletal muscle to the same extent as a complete mixture of amino acids, and the effect occurs through activation of the mechanistic target of rapamycin in complex 1 (mTORC1). Recent studies using cells in culture showed that...

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Dades bibliogràfiques
Publicat a:Am J Physiol Endocrinol Metab
Autors principals: Xu, Dandan, Shimkus, Kevin L., Lacko, Holly A., Kutzler, Lydia, Jefferson, Leonard S., Kimball, Scot R.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6580170/
https://ncbi.nlm.nih.gov/pubmed/30835510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00522.2018
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