ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine Deprivation

BACKGROUND: The protein kinase target of rapamycin (mTOR) in complex 1 (mTORC1) is activated by amino acids and in turn upregulates anabolic processes. Under nutrient-deficient conditions, e.g., amino acid insufficiency, mTORC1 activity is suppressed and autophagy is activated. Intralysosomal amino...

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Vydáno v:J Nutr
Hlavní autoři: Xu, Dandan, Dai, Weiwei, Kutzler, Lydia, Lacko, Holly A, Jefferson, Leonard S, Dennis, Michael D, Kimball, Scot R
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Biochemical, Molecular, and Genetic Mechanisms
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7198311/
https://ncbi.nlm.nih.gov/pubmed/31875479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jn/nxz309
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