The Sestrins interact with GATOR2 to negatively regulate the amino acid sensing pathway upstream of mTORC1

The mTORC1 kinase is a major regulator of cell growth that responds to numerous environmental cues. A key input is amino acids, which act through the heterodimeric Rag GTPases (RagA/B bound to RagC/D) to promote the translocation of mTORC1 to the lysosomal surface, its site of activation. GATOR2 is...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Chantranupong, Lynne, Wolfson, Rachel L., Orozco, Jose M., Saxton, Robert A., Scaria, Sonia M., Bar-Peled, Liron, Spooner, Eric, Isasa, Marta, Gygi, Steven P., Sabatini, David M.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223866/
https://ncbi.nlm.nih.gov/pubmed/25263562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.09.014
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires