The Sestrins interact with GATOR2 to negatively regulate the amino acid sensing pathway upstream of mTORC1

The mTORC1 kinase is a major regulator of cell growth that responds to numerous environmental cues. A key input is amino acids, which act through the heterodimeric Rag GTPases (RagA/B bound to RagC/D) to promote the translocation of mTORC1 to the lysosomal surface, its site of activation. GATOR2 is...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Chantranupong, Lynne, Wolfson, Rachel L., Orozco, Jose M., Saxton, Robert A., Scaria, Sonia M., Bar-Peled, Liron, Spooner, Eric, Isasa, Marta, Gygi, Steven P., Sabatini, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223866/
https://ncbi.nlm.nih.gov/pubmed/25263562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.09.014
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