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Sestrins Inhibit mTORC1 Kinase Activation Through the GATOR Complex
The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a sensor of different environmental conditions and regulator of cell growth, metabolism and autophagy. mTORC1 is activated by Rag GTPases, working as RagA:B and RagC:D heterodimers. Rags control mTORC1 activity by tethering mTORC1 to t...
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| Publicado no: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4303546/ https://ncbi.nlm.nih.gov/pubmed/25457612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.10.019 |
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