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SESTRINs regulate mTORC1 via RRAGs: The riddle of GATOR

SESTRINs, proteins encoded by the SESN1–3 genes in mammals, are well-established suppressors of the mechanistic target of rapamycin complex 1 (mTORC1) kinase. Recently, we found that SESTRINs bind the GATOR2 protein complex, which is a regulator of RRAGA/B guanosine triphosphatase. Three independent...

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Bibliografiske detaljer
Udgivet i:Mol Cell Oncol
Hovedforfatter: Budanov, Andrei V
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905323/
https://ncbi.nlm.nih.gov/pubmed/27308486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2014.997113
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