Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors

Central to cellular proliferative, survival, and metabolic responses is the serine/threonine kinase mTOR, which is activated in many human cancers. mTOR is present in distinct complexes that are either modulated by AKT (mTORC1) or are upstream and regulatory of it (mTORC2). Governance of mTORC2 acti...

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Pubblicato in:Stem Cell Reports
Autori principali: Lee, Dongjun, Sykes, Stephen M., Kalaitzidis, Demetrios, Lane, Andrew A., Kfoury, Youmna, Raaijmakers, Marc H.G.P., Wang, Ying-Hua, Armstrong, Scott A., Scadden, David T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235746/
https://ncbi.nlm.nih.gov/pubmed/25418727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.08.011
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