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Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex

Tuberous sclerosis complex (TSC) is a multisystem genetic disorder with severe neurologic manifestations, including epilepsy, autism, anxiety and attention deficit hyperactivity disorder. TSC is caused by the loss of either the TSC1 or TSC2 genes that normally regulate the mammalian target of rapamy...

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Detalhes bibliográficos
Main Authors: Carson, Robert P., Fu, Cary, Winzenburger, Peggy, Ess, Kevin C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522403/
https://ncbi.nlm.nih.gov/pubmed/23049074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds414
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